My brother has been diagnosed with Fibroblastic Osteosarcoma and has few Osteoblastic bone mets. I wanted to know if Zoledronic acid is of any help to someone with Osteoblastic bone mets. I've read that it usually helps in cases of osteolytic mets but is also used for any type of bone mets. Please advise if administration of zometa will be of any help to someone with Osteoblastic mets?
Hi FearInoculum (Guy),
I’m sorry to hear about your brother’s diagnosis of Fibroblastic Osteosarcoma. It must be a difficult time for your brother and the family. It’s understandable why you’d want to look for further treatment options.
You’re right in saying Zolendronic Acid is more widely used in cancer treatments.
There are some studies to suggest Zolendronic Acid may be helpful in treating Osteosarcoma but unfortunately, these studies conclude further research is needed.
Osteoblastic metastases weaken bones by overproduction of bone-forming cells called osteoblasts. At least one study shows that Zometa inhibits the activity of these cells. Your brother’s oncologist will be aware of that and it may have influenced the choice of treatment.
The Lancet produced an article in 2016. It reported that despite there being over 300 identified studies, only 2 have been published and in each of these reports, the sample size was too small for any conclusion about its effect as a possible treatment for Osteosarcoma.
The National Institutes of Health published an article about the status of chemotherapy treatments for Osteosarcoma, including Zoledronic Acid but this is dated in 2008. Another article published in 2014 suggests Bisphosphonates inhibit the growth of Osteosarcoma.
The bone Cancer Research Trust may have further helpful information on their website. They also carry out clinical trials.
You can look for further clinical trials on the National Institute for Health Research and on Cancer Research UK. CRUK completed a phase 2 trial for advanced Osteosarcoma.
The doctor’s use the NICE government guidelines for the management of bone sarcomas for each person.
I’m sorry we were unable to answer your question directly but as nurses, we follow evidence based practice and unfortunately there appears to be a lack of definitive evidence.
I hope these links are helpful. If you would prefer to chat, please don’t hesitate to contact our Cancer Information Nurse Specialists on our Support Line.
Best wishes and take care,
Hello there -
I apologise for the delay in my response, but I'd like to thank you for such a detailed reply. I had a discussion with my oncologist based on your reply and we did decide to administer Zoledronic acid as it favours in both the cases. Thanks once again and have a great day!
Thanks for getting back in touch with us and letting us know how you got on when you seen your specialist.
I’m glad that you found Gail’s answer helpful and that you have been started on Zoledronic Acid.
Gail is on days off, but I’ll pass on your reply and kind words to her on her return.
Ellen-Macmillan online Digital Nurse Specialist.
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