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Triple Negative treated with Exemestane

GoodHubby
Posted by

My wife had Right Breast grade 2 invasive ductal carcinoma 11mm, no LVI, clear margins, 0/3 sentinel nodes negative, ER 7 PR 7 , HER-2 negative post - op.

She had wide local excision and sentinel lymph node biopsy, Oncotype DX test which showed recurrence of 30.

Chemo 6 cycles with Taxotere.

Further radio therapy in 15 fractions.

4.5 years later is looks like it spread to her brain and she is now having 3 brain tumours removed.

My question is this - if she hormone receptive triple negative with a scale of 7 / 8 for both Estrogen and Progesterone, why would she be treated with Tamoxifen the changed to Exemestane?

Surely these are hormone suppressant and will not have any effect on this kind of BC?

Goodhubby.

Donna - Macmillan
Posted by

Hi GoodHubby,

Thanks for your post. I’m sorry to hear it looks like your wife’s cancer has spread to her brain. I hope the following information helps you to understand a little more about what’s going on.

Triple negative breast cancer means negative for oestrogen receptors, negative for progesterone receptors and HER2 negative.

If your wife has been told she is 7/8 for both oestrogen and progesterone, then this would indicate she has a high number of hormone receptors and would not have triple negative breast cancer. It also means her cancer is likely to respond to hormone therapy in some way. You can read more about the scoring system for this here. You might also wish to read our information on secondary brain cancer as it tells you more about how things can be managed.

Sometimes if the cancer has spread when someone has been on hormone therapy, then doctors might switch to a different drug. Menopausal status can also lead doctors to change the prescription. Your wife’s specialist could chat to you about the reason for switching from tamoxifen to exemestane, if she’s happy for them to do so.

It’s important that when looking after your wife, you’re also taking care of yourself. If you’re taking care of you, then you’ll be more able to support her.

I understand that you’ve been given a lot of information and sometimes this can be confusing. If you feel it would help to have a chat with us, then you can call our support line and ask to speak with a nurse. We’re here each day from 8am to 8pm on 0808 808 00 00.

Take care,

Donna

Cancer Information Nurse Specialist

 

 

Monto15
Posted by

Hi Goodhubby,

I just was just wondering how your wife is and how you and your family are?

Take care

When we have our sad days,it makes us appreciate our happy days. We are not alone on our journey's, we are all here together and supporting each other.x

GoodHubby
Posted by

Hi Monto15

She has had 3 tumours removed , her scar at the back is healing and the staples on the side and top are still in.

I've been looking after her the best I can and she has never eaten so healthily 

She is tired then gets up but still has dizziness and headaches but each day I see a little improvement.

I don't know why but she talks a lot more now?

We have a check up with the consultant neuro surgeon on Tuesday so I guess we will know a lot more after tomorrow.

They said they are happy with post op scans and that they managed to remove the tumours.

I cannot believe how brave she has been and it has helped a lot to talk with as many friends as possible through this.

We really don't know what the future holds in store but each day now is precious to me.

Please don't hesitate to contact me if you want to know anything and thank you for getting back in touch.

I am worn out and just sitting down as I type this with a cuppa.

I really appreciate you!

Monto15
Posted by

Hi Goodhubby,

Amazing news! I am so pleased that you all seem to be doing great!

I guess the tiredness will be catching up with now. Operations over and a good recovery I am sure is now upon you.

Your wife has done fantastically well to get through this,and I bet she is enjoying having her lovely healthy meals put in front of her.

Well done to you Goodhubby.

All the very best to you all.

When we have our sad days,it makes us appreciate our happy days. We are not alone on our journey's, we are all here together and supporting each other.x

GoodHubby
Posted by

Hi Monto15

We went to see the neuro surgeon today and she is an amazing lovely woman who is so full of positivity.

She is very happy that all tumours were successfully removed and showed us the scans and you can clearly see pre and post op scans.

My wife has been referred for some Chemo after 6 weeks so we will see how it goes.

I suppose we will learn more as we go forward.

Goodhubby.

Monto15
Posted by

Hi Goodhubby

That's brilliant news!

We have not long since come back from my partner having chemo today.It does actually become part of 'normality'.

Tomorrow we have a review of which we will I'm sure receive the latest scan results, quietly to myself I am dreading it.

I know I have to remain strong and positive, but it sometimes is easier said than done.

I really am so pleased for you and your wife,it has been a traumatic time for you both, but you are both emerging through the other side, with I am sure good things to look forward to.

Thanks for your update.

Take care, both of you.

When we have our sad days,it makes us appreciate our happy days. We are not alone on our journey's, we are all here together and supporting each other.x