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Squamous metaplasia

Posted by


I had a hematuria in my urine in December.

I have had a rigid cystoscopy with biopsies.

Been for my follow up today and have squamous metaplasia. 

The surgeon has now discharged me.

Could you explain what this is exactly and is there a cancer risk? I had breast cancer 2 years ago.

Thank you

Ellen M-Macmillan
Posted by


Thanks for getting in touch with us.

It’s natural to worry about symptoms you’re having especially when you’ve had a previous history of breast cancer.

It’s great news that your biopsy results have not shown cancer and that the surgeon has discharged you from his care. But it’s understandable why you’re asking more questions.

Squamous metaplasia of the bladder is not cancer. Non-keratinized squamous metaplasia is one of a variety of normal cell types and found commonly in women in the trigone area of the bladder. This is the triangular shaped area on the back wall of the bladder. This doesn’t increase your risk of developing a bladder cancer.

The other histological type of squamous metaplasia is a keratinizing squamous metaplasia, this is rarer. This can increase someone’s risk of developing bladder cancer especially if the cells are not typical and show abnormal early signs of abnormal cells within the tissue (dysplasia). Usually if this was reported on a pathology report doctors would follow up someone up. This allows the doctors to detect early changes that could develop into cancer earlier.

Because you don’t feel as if the doctors explained what the implications of your pathology meant, we would advise that you go back and speak to them again. Or ask your GP if they could go over your pathology report in more detail with you. This should make it clear what type of metaplasia was found in your biopsy. Hopefully this will relieve some of the anxiety you must be feeling.

Take care

Ellen-Macmillan Online Digital Nurse Specialist.